The role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital heart disease: a systematic review and meta-analysis (Protocol)

Wadey, C. A., Weston, M. E., Dorobantu, D. M., Taylor, R. S. , Pieles, G. E., Barker, A. R. and Williams, C. A. (2020) The role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital heart disease: a systematic review and meta-analysis (Protocol). Journal of Congenital Cardiology, 4, 4. (doi: 10.1186/s40949-020-00035-x)

Abstract

Background: Numerous studies have measured the prognostic associations between cardiorespiratory fitness and patient outcomes in congenital heart disease, but no systematic review has assessed these associations for all types of congenital heart disease. It is therefore a timely opportunity to syntheses all available data using a systematic review methodology. The aim of this study is to detail the protocol for a systematic review and meta-analysis. Objectives: Within this paper we have developed a protocol for a prognostic factors systematic review and meta-analysis, to assess the role of cardiopulmonary exercise testing/cardiorespiratory fitness, in the prognosis of mortality and morbidity in congenital heart disease. Methods: We have outlined, in detail, the process for this systematic review using the latest accepted methodological guidelines for prognostic factors research, such as the PICOTS system, CHARMS-PF data extraction, QUIPS risk of bias assessments and the prognostic GRADE guidelines (see list of abbreviations). Conclusion: The implications of this review will aid future treatments, interventions and individual patient risk prediction. The publication of this protocol aims to improve scientific rigour by ensuring transparency in the systematic review and meta-analysis process.

• Item Type: Articles
• Additional Information: CA Wadey is funded by an industrial PhD scholarship by Canon Medical Systems UK Ltd. and the University of Exeter. MEW is funded by a PhD scholarship from the QUEX institute and DMD is funded by the Medical Research Council.
• Keywords: Review, Cardiorespiratory fitness, Exercise test, Mortality, Morbidity, Prognosis, Congenital heart, Systematic review
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Taylor, Professor Rod
• Authors: Wadey, C. A., Weston, M. E., Dorobantu, D. M., Taylor, R. S., Pieles, G. E., Barker, A. R., and Williams, C. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
• Journal Name: Journal of Congenital Cardiology
• Publisher: BioMed Central
• ISSN: 2056-7251
• ISSN (Online): 2056-7251
• Copyright Holders: Copyright © The Author(s) 2020
• First Published: First published in Journal of Congenital Cardiology 4:4
• Publisher Policy: Reproduced under a Creative Commons Licence