Tsofliou, F., Pitsiladis, Y. P., Lara, J., Hadjicharalambous, M., Macdonald, I. A., Wallace, M. A. and Lean, M. E.J. (2020) The effects of moderate alterations in adrenergic activity on acute appetite regulation in obese women: a randomised crossover trial. Nutrition and Health, 26(4), pp. 311-322. (doi: 10.1177/0260106020942117) (PMID:32729763)
Text
224005.pdf - Published Version Available under License Creative Commons Attribution. 337kB |
Abstract
Background: Previous evidence has demonstrated that serum leptin is correlated with appetite in combination with, but not without, modest exercise. Aim: The present experiments investigated the effects of exogenous adrenaline and α/β adrenoceptor blockade in combination with moderate exercise on serum leptin concentrations, appetite/satiety sensations and subsequent food intake in obese women. Methods: A total of 10 obese women ((mean ± SEM), age: 50 (1.9) years, body mass index 36 (4.1) kg/m2, waist 104.8 (4.1) cm) participated in two separate, double-blind randomised experimental trials. Experiment 1: moderate exercise after α/β adrenergic blocker (labetalol, 100 mg orally) versus moderate exercise plus placebo; experiment 2: adrenaline infusion for 20 minutes versus saline infusion. Appetite/satiety and biochemistry were measured at baseline, pre- and immediately post-intervention, then 1 hour post-intervention (i.e., before dinner). Food intake was assessed via ad libitum buffet-style dinner. Results: No differences were found in appetite/satiety, subsequent food intake or serum leptin in any of the studies (experiment 1 or experiment 2). In experiment 1, blood glucose was higher (p < 0.01) and plasma free fatty acids lower (p = 0.04) versus placebo. In experiment 2, plasma free fatty acids (p < 0.05) increased after adrenaline versus saline infusion. Conclusions: Neither inhibition of exercise-induced adrenergic activity by combined α/β adrenergic blockade nor moderate increases in adrenergic activity induced by intravenous adrenaline infusion affected acute appetite regulation.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lean, Professor Michael and Pitsiladis, Dr Yannis |
Authors: | Tsofliou, F., Pitsiladis, Y. P., Lara, J., Hadjicharalambous, M., Macdonald, I. A., Wallace, M. A., and Lean, M. E.J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Nutrition and Health |
Publisher: | SAGE |
ISSN: | 0260-1060 |
ISSN (Online): | 2047-945X |
Published Online: | 30 July 2020 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in Nutrition and Health 26(4):311-322 |
Publisher Policy: | Reproduced under a Creative Commons licence |
University Staff: Request a correction | Enlighten Editors: Update this record