Neurodevelopmental toxicities: teratogens and early adversity

Thomson, A., Hind, R., Donaldson, J., Adey, C. and Dorris, L. (2022) Neurodevelopmental toxicities: teratogens and early adversity. In: Della Sala, S. (ed.) Encyclopedia of Behavioral Neuroscience [2nd ed.]. Elsevier, pp. 312-319. ISBN 9780128093245 (doi: 10.1016/B978-0-12-819641-0.00053-0)

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We review in utero exposure to agents causing developmental toxicities, which are in combination a major cause of early brain injury and neurodevelopmental disorders. The term developmental toxicity has become increasingly used and recognizes that toxic exposures can lead to more than structural congenital abnormalities, and can be associated with a range of cognitive, behavioral and developmental deficits in the absence of major brain and CNS malformations. We review the evidence of harm associated with exposure to commonly prescribed psychotropic medications, as well as alcohol, tobacco and illicit drugs. We also consider recent evidence of the impact of severe abuse and neglect and non-optimal early environments as mediators and moderators of brain development.

Item Type:Book Sections (Encyclopaedia entry)
Glasgow Author(s) Enlighten ID:Adey, Claire and Dorris, Professor Liam
Authors: Thomson, A., Hind, R., Donaldson, J., Adey, C., and Dorris, L.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Published Online:17 September 2021

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