Role of late photons in diffuse optical imaging

Radford, J. , Lyons, A. , Tonolini, F. and Faccio, D. (2020) Role of late photons in diffuse optical imaging. Optics Express, 28(20), pp. 29486-29495. (doi: 10.1364/OE.402503)

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The ability to image through turbid media, such as organic tissues, is a highly attractive prospect for biological and medical imaging. This is challenging, however, due to the highly scattering properties of tissues which scramble the image information. The earliest photons that arrive at the detector are often associated with ballistic transmission, whilst the later photons are associated with complex paths due to multiple independent scattering events and are therefore typically considered to be detrimental to the final image formation process. In this work, we report on the importance of these highly diffuse, “late” photons for computational time-of-flight diffuse optical imaging. In thick scattering materials, >80 transport mean free paths, we provide evidence that including late photons in the inverse retrieval enhances the image reconstruction quality. We also show that the late photons alone have sufficient information to retrieve images of a similar quality to early photon gated data. This result emphasises the importance in the strongly diffusive regime of fully time-resolved imaging techniques.

Item Type:Articles
Additional Information:The authors acknowledge funding from EPSRC (UK, grant no. EP/T00097X/1). DF is supported by the Royal Academy of Engineering under the Chairs in Emerging Technologies scheme. JR is supported by the EPSRC Centre for Doctoral Training in Intelligent Sensing and Measurement, Grant Number EP/L016753/1. FT is supported by Amazon and EPSRC grant EP/M01326X/1.
Glasgow Author(s) Enlighten ID:Faccio, Professor Daniele and Tonolini, Francesco and Radford, Jack and Lyons, Dr Ashley
Authors: Radford, J., Lyons, A., Tonolini, F., and Faccio, D.
College/School:College of Science and Engineering
College of Science and Engineering > School of Physics and Astronomy
Journal Name:Optics Express
Publisher:Optical Society of America
ISSN (Online):1094-4087
Copyright Holders:Copyright © 2020 Optical Society of America
First Published:First published in Optics Express 28(20:29486-29495
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190841UK Quantum Technology Hub in Enhanced Quantum ImagingMiles PadgettEngineering and Physical Sciences Research Council (EPSRC)EP/M01326X/1P&S - Physics & Astronomy
305567QuantIC - The UK Quantum Technoogy Hub in Quantum Enhanced ImagingMiles PadgettEngineering and Physical Sciences Research Council (EPSRC)EP/T00097X/1P&S - Physics & Astronomy
190828EPSRC Centre for Doctoral Training in Sensing and MeasurementAndrew HarveyEngineering and Physical Sciences Research Council (EPSRC)EP/L016753/1P&S - Physics & Astronomy