Flagellum assembly and function during the Leishmania life cycle

Gluenz, E. , Ginger, M. L. and McKean, P. G. (2010) Flagellum assembly and function during the Leishmania life cycle. Current Opinion in Microbiology, 13(4), pp. 473-479. (doi: 10.1016/j.mib.2010.05.008) (PMID:20541962)

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Abstract

During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the ‘rudimentary’ amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages.

Item Type:Articles
Additional Information:Work in the authors’ laboratories is supported by grants from the Biotechnology and Biological Sciences Research Council (BBSRC), The Royal Society and The Wellcome Trust. MLG is a Royal Society University Research Fellow.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gluenz, Dr Eva
Authors: Gluenz, E., Ginger, M. L., and McKean, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Microbiology
Publisher:Elsevier
ISSN:1369-5274
ISSN (Online):1879-0364
Published Online:11 June 2010

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