Parra Soto, S. L., Ho, F. K., Pell, J. P. and Celis-Morales, C. (2020) Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites? British Journal of Cancer, 123, pp. 1697-1704. (doi: 10.1038/s41416-020-01059-1) (PMID:32921791)
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Abstract
Background: Whether the association of height with cancers differs by insulin-like growth factors has not been fully elucidated. Therefore, this study aimed to investigate the sex-specific associations between height and 24 site-specific cancers and to assess whether the association differed by IGF-1. Methods: In total, 414,923 participants from the UK Biobank prospective cohort study were included. The association of height (per 5-cm increment) with incidence and mortality from 24 cancer sites was investigated by using Cox proportional hazard models. Results: The median follow-up was 6.0 years. In men, height was positively associated with incidence risk of all-cause cancer and at five sites (lung, lymphatic, leukaemia, non-Hodgkin lymphoma and melanoma). In women, it was associated with breast, melanoma, lymphatic, non-Hodgkin lymphoma and all-cause cancer. The association was stronger in women than men for all-cause cancer incidence. The strength of the association did not differ by IGF-1 concentration. Conclusions: Adult height was associated with risk of several cancer sites. However, some of these associations were sex-specific. There was no strong evidence to support IGF-1 moderating the association between height and cancer.
Item Type: | Articles |
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Additional Information: | Funding: SPS was funded by the Chilean Government PhD scholarship program. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ho, Dr Frederick and Parra, Solange and Celis, Dr Carlos and Pell, Professor Jill |
Authors: | Parra Soto, S. L., Ho, F. K., Pell, J. P., and Celis-Morales, C. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | British Journal of Cancer |
Publisher: | Springer Nature |
ISSN: | 0007-0920 |
ISSN (Online): | 1532-1827 |
Published Online: | 14 September 2020 |
Copyright Holders: | Copyright © 2020 Springer Nature |
First Published: | First published in British Journal of Cancer 123:1697-1704 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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