Induction and transmission of oncogene-induced senescence

Rattanavirotkul, N., Kirschner, K. and Chandra, T. (2021) Induction and transmission of oncogene-induced senescence. Cellular and Molecular Life Sciences, 78(3), pp. 843-852. (doi: 10.1007/s00018-020-03638-0) (PMID:32936311) (PMCID:PMC7897614)

Abstract

Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kirschner, Dr Kristina
• Authors: Rattanavirotkul, N., Kirschner, K., and Chandra, T.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Cellular and Molecular Life Sciences
• Publisher: Springer
• ISSN: 1420-682X
• ISSN (Online): 1420-9071
• Published Online: 16 September 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Cellular and Molecular Life Sciences 78(3): 843-852
• Publisher Policy: Reproduced under a Creative Commons license