Induction and transmission of oncogene-induced senescence

Rattanavirotkul, N., Kirschner, K. and Chandra, T. (2021) Induction and transmission of oncogene-induced senescence. Cellular and Molecular Life Sciences, 78(3), pp. 843-852. (doi: 10.1007/s00018-020-03638-0) (PMID:32936311) (PMCID:PMC7897614)

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Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kirschner, Dr Kristina
Authors: Rattanavirotkul, N., Kirschner, K., and Chandra, T.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cellular and Molecular Life Sciences
ISSN (Online):1420-9071
Published Online:16 September 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Cellular and Molecular Life Sciences 78(3): 843-852
Publisher Policy:Reproduced under a Creative Commons license

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