A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer

Dolan, R. D. , Alwahid, M., McSorley, S. T. , Park, J. H. , Stevenson, R. P., Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, 17965. (doi: 10.1038/s41598-020-73909-0) (PMID:33087753) (PMCID:PMC7578034)

Abstract

The aim of this study was to directly compare the prognostic value of cumulative scores and composite ratios in patients with operable rectal cancer. Within a single surgical unit preoperative differential blood cell results including neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, as well as CRP (C) and albumin (A) levels were recorded. These results were used to construct a series of composite ratios (NLR, PLR, LMR, CAR) and cumulative scores (NLS, PLS, LMS, NPS, mGPS). The relationship between composite ratios and the cumulative scores and clinicopathological characteristics, cancer specific survival (CSS) and overall survival (OS) were examined. A total of 413 patients were included. When adjusted for TNM stage, surgical approach, time of surgery and margin involvement mGPS (p < 0.05) was associated with CSS. In addition, most composite ratios/scores showed correlations with neoadjuvant therapy (p < 0.001). When a direct comparison between NPS (myeloid) and mGPS (liver) was carried out they showed similar associations with both CSS and OS. Therefore, both composite ratios and cumulative scores have been shown to be prognostic in patients with operable rectal cancer.

• Item Type: Articles
• Additional Information: This research was funded by the University of Glasgow.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Park, Mr James and Horgan, Professor Paul and McSorley, Dr Stephen and Stevenson, Dr Richard and McMillan, Professor Donald and Roxburgh, Professor Campbell and Dolan, Dr Ross
• Authors: Dolan, R. D., Alwahid, M., McSorley, S. T., Park, J. H., Stevenson, R. P., Roxburgh, C. S., Horgan, P. G., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Scientific Reports
• Publisher: Nature Research
• ISSN: 2045-2322
• ISSN (Online): 2045-2322
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Scientific Reports 10: 17965
• Publisher Policy: Reproduced under a Creative Commons License