Altered autonomic function in individuals at clinical high risk for psychosis

Kocsis, A., Gajwani, R. , Gross, J. , Gumley, A. I. , Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Grent-'t-Jong, T. and Uhlhaas, P. J. (2020) Altered autonomic function in individuals at clinical high risk for psychosis. Frontiers in Psychiatry, 11, 580503. (doi: 10.3389/fpsyt.2020.580503)

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Abstract

Introduction: Alterations in autonomic functioning in individuals diagnosed with schizophrenia are well-documented. Yet, it is currently unclear whether these dysfunctions extend into the clinical high-risk state. Thus, we investigated resting heart rate (RHR) and heart rate variability (HRV) indices in individuals at clinical high-risk for psychosis (CHR-P). Methods: We recruited 117 CHR-P participants, 38 participants with affective disorders and substance abuse (CHR-N) as well as a group of 49 healthy controls. CHR-P status was assessed with the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Schizophrenia Proneness Instrument, Adult Version (SPI-A). We obtained 5 min, eyes-open resting-state MEG data, which was used for the extraction of cardiac field-related inter-beat-interval data and from which heart-rate and heart-rate variability measures were computed. Results: Compared to both CHR-N and healthy controls, CHR-P participants were characterized by an increased RHR, which was not explained by differences in psychopathological comorbidity and medication status. Increased RHR correlated with the presence of subthreshold psychotic symptoms and associated distress. No differences between groups were found for heart-rate variability measures, however. Furthermore, there was an association between motor-performance and psychophysiological measures. Conclusion: The current study provides evidence of alterations in autonomic functioning as disclosed by increased RHR in CHR-P participants. Future studies are needed to further evaluate this characteristic feature of CHR-P individuals and its potential predictive value for psychosis development.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Gross, Professor Joachim and Grent-'T-Jong, Dr Tineke and Gumley, Professor Andrew and Kocsis, Miss Anna and Gajwani, Dr Ruchika
Authors: Kocsis, A., Gajwani, R., Gross, J., Gumley, A. I., Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Grent-'t-Jong, T., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Frontiers in Psychiatry
Publisher:Frontiers Media
ISSN:1664-0640
ISSN (Online):1664-0640
Copyright Holders:Copyright © 2020 Kocsis, Gajwani, Gross, Gumley, Lawrie, Schwannauer, Schultze- Lutter, Grent-‘t-Jong and Uhlhaas
First Published:First published in Frontiers in Psychiatry 11: 580503
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190713Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1NP - Centre for Cognitive Neuroimaging (CCNi)