The riveting cellular structures in Apicomplexan parasites

Harding, C. R. and Frischnknecht, F. (2020) The riveting cellular structures in Apicomplexan parasites. Trends in Parasitology, 36(12), pp. 979-991. (doi: 10.1016/ (PMID:33011071)

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Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal diseases. Their complex life cycles – often heteroxenous with sexual and asexual phases in different hosts – rely on elaborate cytoskeletal structures to enable morphogenesis and motility, organize cell division, and withstand diverse environmental forces. This review primarily focuses on studies using Toxoplasma gondii and Plasmodium spp. as the best studied apicomplexans; however, many cytoskeletal adaptations are broadly conserved and predate the emergence of the parasitic phylum. After decades cataloguing the constituents of such structures, a dynamic picture is emerging of the assembly and maintenance of apicomplexan cytoskeletons, illuminating how they template and orient critical processes during infection. These observations impact our view of eukaryotic diversity and offer future challenges for cell biology.

Item Type:Articles
Additional Information:C.R.H. is funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (213455/Z/18/Z) and a Lord Kelvin/Adam Smith (LKAS) Fellowship from the University of Glasgow. F.F. is a member of the SFB 1129 at Heidelberg University.
Keywords:Apicomplexa, Plasmodium, Toxoplasma, cytoskeleton, motility, invasion, 13 cell division, pellicle, inner membrane complex, microtubules, subpellicular network.
Glasgow Author(s) Enlighten ID:Harding, Dr Clare
Authors: Harding, C. R., and Frischnknecht, F.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Trends in Parasitology
Publisher:Elsevier (Cell Press)
ISSN (Online):1471-5007
Published Online:30 September 2020
Copyright Holders:Copyright © 2020 The Author(s)
First Published:First published in Trends in Parasitology 36(12): 979-991
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304336Iron usage in the eukaryotic parasite Toxoplasma gondiiClare HardingWellcome Trust (WELLCOTR)213455/Z/18/ZIII - Parasitology