Lyall, D. M. , Ward, J. , Banach, M., Smith, G. D., Gill, J. G. , Pell, J. P. , Holmes, M. V. and Sattar, N. (2021) PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study. Archives of Medical Science, 17(1), pp. 241-244. (doi: 10.5114/aoms/127226)
Text
222866.pdf - Published Version Available under License Creative Commons Attribution Non-commercial Share Alike. 63kB |
Abstract
Introduction: PCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function. Methods: We examined the association of genetic variants in PCSK9 with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in PCSK9 were used in up to 337,348 individuals. Results: The PCSK9 allele score was associated with a lower risk of CHD, and weakly with worse log reaction time. Conclusions: We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ward, Dr Joey and Gill, Professor Jason and Pell, Professor Jill and Sattar, Professor Naveed and Lyall, Dr Donald |
Authors: | Lyall, D. M., Ward, J., Banach, M., Smith, G. D., Gill, J. G., Pell, J. P., Holmes, M. V., and Sattar, N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Archives of Medical Science |
Publisher: | Termedia |
ISSN: | 1734-1922 |
ISSN (Online): | 1896-9151 |
Copyright Holders: | Copyright © 2020 Termedia & Banach |
First Published: | First published in Archives of Medical Science 17(1):241–244 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record