Damasceno, J. D., Marques, C. A., Black, J., Briggs, E. and McCulloch, R. (2021) Read, write, adapt: challenges and opportunities during kinetoplastid genome replication. Trends in Genetics, 37(1), pp. 21-34. (doi: 10.1016/j.tig.2020.09.002) (PMID:32993968) (PMCID:PMC9213392)
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Abstract
The genomes of all organisms are read throughout their growth and development, generating new copies during cell division and encoding the cellular activities dictated by the genome’s content. However, genomes are not invariant information stores but are purposefully altered in minor and major ways, adapting cellular behaviour and driving evolution. Kinetoplastids are eukaryotic microbes that display a wide range of such read–write genome activities, in many cases affecting critical aspects of their biology, such as host adaptation. Here we discuss the range of read–write genome changes found in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishmania, focusing on recent work that suggests such adaptive genome variation is linked to novel strategies the parasites use to replicate their unconventional genomes.
| Item Type: | Articles |
|---|---|
| Additional Information: | This publication was supported by the BBSRC [BB/N016165/1, BB/R017166/1], the MRC [MR/S019472/1], and has received funding from European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 750259 [Individual Fellowship, RECREPEMLE]. The Wellcome Centre for Integrative Parasitology is supported by core funding from the Wellcome Trust [104111]. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Black, Dr Jennifer Ann and Damasceno, Dr Jeziel and Briggs, Miss Emma and McCulloch, Professor Richard |
| Authors: | Damasceno, J. D., Marques, C. A., Black, J., Briggs, E., and McCulloch, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Genetics |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 0168-9525 |
| ISSN (Online): | 1362-4555 |
| Published Online: | 28 September 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in Trends in Genetics 37(1): 21-34 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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