Initial results from the Royal College of Radiologists' UK national audit of anal cancer radiotherapy 2015

Muirhead, R., Drinkwater, K., O'Cathail, S.M. , Adams, R., Glynne-Jones, R., Harrison, M., Hawkins, M.A., Sebag-Montefiore, D. and Gilbert, D.C. (2017) Initial results from the Royal College of Radiologists' UK national audit of anal cancer radiotherapy 2015. Clinical Oncology, 29(3), pp. 188-197. (doi: 10.1016/j.clon.2016.10.005) (PMID:27810119) (PMCID:PMC5304408)

Abstract

Aims: UK guidance was recently developed for the treatment of anal cancer using intensity-modulated radiotherapy (IMRT). We audited the current use of radiotherapy in UK cancer centres for the treatment of anal cancer against such guidance. We describe the acute toxicity of IMRT in comparison with patient population in the audit treated with two-phase conformal radiotherapy and the previous published data from two-phase conformal radiotherapy, in the UK ACT2 trial. Materials and methods: A Royal College of Radiologists' prospective national audit of patients treated with radiotherapy in UK cancer centres was carried out over a 6 month period between February and July 2015. Results: Two hundred and forty-two cases were received from 40/56 cancer centres (71%). In total, 231 (95%) underwent full dose radiotherapy with prophylactic nodal irradiation. Of these, 180 (78%) received IMRT or equivalent, 52 (22%) two-phase conformal (ACT2) technique. The number of interruptions in radiotherapy treatment in the ACT2 trial was 15%. Interruptions were noted in 7% (95% confidence interval 0–14%) of courses receiving two-phase conformal and 4% (95% confidence interval 1–7%) of those receiving IMRT. The percentage of patients completing the planned radiotherapy dose, irrelevant of gaps, was 90% (95% confidence interval 82–98%) and 96% (95% confidence interval 93–99%), in two-phase conformal and IMRT respectively. The toxicity reported in the ACT2 trial, in patients receiving two-phase conformal in the audit and in patients receiving IMRT in the audit was: any toxic effect 71%, 54%, 48%, non-haematological 62%, 49%, 40% and haematological 26%, 13%, 18%, respectively. Conclusions: IMRT implementation for anal cancer is well underway in the UK with most patients receiving IMRT delivery, although its usage is not yet universal. This audit confirms that IMRT results in reduced acute toxicity and minimised treatment interruptions in comparison with previous two-phase conformal techniques.

• Item Type: Articles
• Additional Information: RM and MAH are supported by MRC grant MC_PC_12001/2.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: O'Cathail, Dr Sean
• Authors: Muirhead, R., Drinkwater, K., O'Cathail, S.M., Adams, R., Glynne-Jones, R., Harrison, M., Hawkins, M.A., Sebag-Montefiore, D., and Gilbert, D.C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Clinical Oncology
• Publisher: Elsevier
• ISSN: 0936-6555
• ISSN (Online): 1433-2981
• Published Online: 31 October 2016
• Copyright Holders: Copyright © 2016 The Royal College of Radiologists
• First Published: First published in Clinical Oncology 29(3): 188-197
• Publisher Policy: Reproduced under a Creative Commons License