Sensing polymer/paracetamol interaction with an independent component analysis-based SERS-MIP nanosensor

Decorbie, N. et al. (2020) Sensing polymer/paracetamol interaction with an independent component analysis-based SERS-MIP nanosensor. Plasmonics, 15, pp. 1533-1539. (doi: 10.1007/s11468-020-01177-9)

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In this article, we propose a new strategy to build a sensor for easy handling and rapid analysis on-site. Our sensor is based on the combination of surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs). SERS provides a strong sensitivity for the detection of trace molecules while MIPs offer a highly selective and specific recognition platform. The research presented here focuses on the detection of the interaction between a robust ultra-thin layer of MIPs and of paracetamol, the targeted molecule. This drug is an environmental emerging pollutant, i.e., a molecule whose presence and significance have not yet been elucidated, which gives rise to health and environmental concerns. The results are a combined analysis of the SERS spectra and a multivariate analysis. The former provides a clear demonstration of the evolution of the MIP-nanostructure interaction when the concentration of paracetamol increases. The statistical analysis produces the proof of the selectivity of the sensor.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gauchotte-Lindsay, Dr Caroline
Authors: Decorbie, N., Tijunelyte, I., Gam-Derouich, S., Solard, J., Lamouri, A., Decorse, P., Felidj, N., Gauchotte-Lindsay, C., Rinnert, E., Mangeney, C., and Lidgi-Guigui, N.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Plasmonics
ISSN (Online):1557-1963
Published Online:01 May 2020

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