Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling

O'Toole, D., Zaeri, A. A. I., Nicklin, S. A. , French, A. T., Loughrey, C. M. and Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, 109770. (doi: 10.1016/j.cellsig.2020.109770) (PMID:32891693)

Abstract

Adverse cardiac remodelling clinically manifests as deleterious changes to heart architecture (size, mass and geometry) and function. These changes, which include alterations to ventricular wall thickness, chamber dilation and poor contractility, are important because they progressively drive patients with cardiac disease towards heart failure and are associated with poor prognosis. Cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ECM), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. In this review, we highlight the role of cathepsins in these signalling pathways as well as their translational potential as therapeutic targets in cardiac disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Martin, Dr Tamara and O'Toole, Mr Dylan and French, Professor Anne and Loughrey, Professor Christopher and Nicklin, Professor Stuart and Zaeri, Ali Abdullah I
• Authors: O'Toole, D., Zaeri, A. A. I., Nicklin, S. A., French, A. T., Loughrey, C. M., and Martin, T. P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Cellular Signalling
• Publisher: Elsevier
• ISSN: 0898-6568
• ISSN (Online): 1873-3913
• Published Online: 04 September 2020
• Copyright Holders: Crown Copyright © 2020
• First Published: First published in Cellular Signalling 76:109770
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
301985		Investigating the Therapeutic Potential of Runx1 for Myocardial Infarction	Christopher Loughrey	British Heart Foundation (BHF)	PG/18/9/33548	CAMS - Cardiovascular Science