Dowsett, L. , Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C. and Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)
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Abstract
Atherosclerosis is a chronic cardiovascular disease which increases risk of major cardiovascular events including myocardial infarction and stroke. Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) have long been recognised as a hallmark of cardiovascular disease and are associated with cardiovascular risk factors including hypertension, obesity and hypertriglyceridemia. In this review, we discuss the clinical literature that link ADMA concentrations to increased risk of the development of atherosclerosis. The formation of atherosclerotic lesions relies on the interplay between vascular dysfunction, leading to endothelial activation and the accumulation of inflammatory cells, particularly macrophages, within the vessel wall. Here, we review the mechanisms through which elevated ADMA contributes to endothelial dysfunction, activation and reactive oxygen species (ROS) production; how ADMA may affect vascular smooth muscle phenotype; and finally whether ADMA plays a regulatory role in the inflammatory processes occurring within the vessel wall.
Item Type: | Articles |
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Additional Information: | The Institute of Cardiovascular and Medical Sciences is a recipient of a British Heart Foundation Centre of Research Excellence Award (RE/13/5/30177). E.H. is a recipient of a British Heart Foundation 4 year studentship (FS/17/63/33485). S.A. is funded by Al-Jouf University, Saudi Arabia. N.A. is funded by the King Saud University, Saudi Arabia. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Alanazi, Sarah and Leiper, Dr Fiona and Dowsett, Dr Laura and Leiper, Professor James and Alshuwayer, Noha and Higgins, Miss Erin |
Creator Roles: | Dowsett, L.Conceptualization, Writing – original draft, Writing – review and editing, Visualization Higgins, E.Writing – original draft, Writing – review and editing Alanazi, S.Writing – original draft, Writing – review and editing Alshuwayer, N.Writing – original draft, Writing – review and editing Leiper, F.Writing – review and editing Leiper, J.Conceptualization, Writing – review and editing, Supervision, Funding acquisition |
Authors: | Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., and Leiper, J. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Clinical Medicine |
Publisher: | MDPI |
ISSN: | 2077-0383 |
ISSN (Online): | 2077-0383 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in Journal of Clinical Medicine 9(9):3026 |
Publisher Policy: | Reproduced under a Creative Commons License |
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