Mitochondrial physiology

Gnaiger, E. et al. (2020) Mitochondrial physiology. Bioenergetic Communications, 2020(1), (doi: 10.26124/bec:2020-0001.v1)

Abstract

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.

• Item Type: Articles
• Additional Information: This publication is based upon work from COST Action MitoEAGLE, supported by COST (European Cooperation in Science and Technology), in cooperation with COST Actions CA16225 EU-CARDIOPROTECTION and CA17129 CardioRNA; K-Regio project MitoFit funded by the Tyrolian Government, and project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 859770.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mercer, Dr John
• Authors: Gnaiger, E., Aasander Frostner, E., Abdul Karim, N., Abdel-Rahman, E. A., Abumrad, N. A., Acuna-Castroviejo, D., Adiele, R. C., Ahn, B., Alencar, M., Ali, S. S., Alton, L., Alves, M. G., Amati, F., Amoedo, N. D., Amorim, R., Anderson, E. J., Andreadou, I., Antunes, D., Arago, M., Aral, C., Arandarcikaite, O., Arias-Reyes, C., Armand, A.-S., Arnould, T., Avram, V. F., Axelrod, C. L., Bairam, A., Bailey, D. M., Bajpeyi, S., Bajzikova, M., Bakker, B. M., Barlow, J., Bardal, T., Banni, A., Bastos Sant'Anna Silva, A. C., Batterson, P., Battino, M., Bazil, J., Beard, D. A., Beleza, J., Bednarczyk, P., Bello, F., Ben-Shachar, D., Bergdahl, A., Berge, R. K., Bergmeister, L., Bernardi, P., Berridge, M. V., Bettinazzi, S., Bishop, D., Blier, P. U., Blindheim, D. F., Boardman, N. T., Boetker, H. E., Borchard, S., Boros, M., Borsheim, E., Borras, C., Borutaite, V., Botella, J., Bouillaud, F., Bouitbir, J., Boushel, R. C., Bovard, J., Bravo-Sagua, R., Breton, S., Brown, D. A., Brown, G. C., Brown, R. A., Brozinick, J. T., Buettner, G. R., Burtscher, J., Bustos, M., Calabria, E., Calbet, J. A., Calzia, E., Cannon, D. T., Cano Sanchez, M., Canto Alvarez, C., Cardinale, D., Cardoso, L. H. D., Carvalho, E., Casado Pinna, M., Cassar, S., Castelo, M. P., Castilho, R. F., Cavalcanti-de-Albuquerque, J. P., Cecatto, C., Celen, M. C., Cervinkova, Z., Chabi, B., Chakrabarti, L., Chakrabarti, S., Chaurasia, B., Chen, Q., Chicco, A. J., Chinopoulos, C., Chowdhury, S. K., Cizmarova, B., Clementi, E., Coen, P. M., Cohen, B. H., Coker, R. H., Collin-Chenot, A., Coughlan, M., Coxito, P., Crisostomo, L., Crispim, M., Crossland, H., Dahdah, N., Dalgaard, L. T., Dambrova, M., Danhelovska, T., Darveau, C. A., Darwin, P. M., Das, A. M., Dash, R. K., Davidova, E., Davis, M. S., Dayanidhi, S., De Bem, A. F., De Goede, P., De Palma, C., De Pinto, V., Dela, F., Dembinska-Kiec, A., Detraux, D., Devaux, Y., Di Marcello, M., Di Paola, F. J., Dias, C., Dias, T. R., Distefano, G., Djafarzadeh, S., Doermann, N., Doerrier, C., Dong, L.-F., Donnelly, C., Drahota, Z., Duarte, F. V., Dubouchaud, H., Duchen, M. R., Dumas, J.-F., Durham, W. J., Dymkowska, D., Dyrstad, S. E., Dyson, A., Dzialowski, E. M., Eaton, S., Ehinger, J., Elmer, E., Endlicher, R., Engin, A. B., Escames, G., Evinova, A., Ezrova, Z., Falk, M. J., Fell, D. A., Ferdinandy, P., Ferko, M., Fernandez-Ortiz, M., Fernandez-Vizarra, E., Ferreira, J. C. B., Ferreira, R., Ferri, A., Festuccia, W., Fessel, J. P., Filipovska, A., Fisar, Z., Fischer, C., Fischer, M., Fisher, G., Fisher, J. J., Fontanesi, F., Forbes-Hernandez, T. Y., Ford, E., Fornaro, M., Fuertes Agudo, M., Fulton, M., Galina, A., Galkin, A., Gallee, L., Galli, G. L., Gama Perez, P., Gan, Z., Ganetzky, R., Gao, Y., Garcia, G. S., Garcia-Rivas, G., Garcia-Roves, P. M., Garcia-Souza, L. F., Garlid, K. D., Garrabou, G., Garten, A., Gastaldelli, A., Gayen, J., Genders, A. J., Genova, M. L., Giampieri, F., Giovarelli, M., Glatz, J. F., Goikoetxea Usandizaga, N., Goncalo Teixeira da Silva, R., Goncalves, D. F., Gonzalez-Armenta, J. L., >Gonzalez-Francesqua, A., Gonzalez-Freire, M., Gonzalo, H., Goodpaster, B. H., Gorr, T. A., Gourlay, C. W., Grams, B., Granata, C., Grefte, S., Grilo, L., Guarch, M. E., Gueguen, N., Gumeni, S., Haas, C. B., Haavik, J., Hachmo, Y., Haendeler, J., Haider, M., Hajrulahovic, A., Hamann, A., Han, J., Han, W. H., Hancock, C. R., Hand, S. C., Handl, J., Hansikova, H., Hardee, J. P., Hargreaves, I. P., Harper, M. E., Harrison, D. K., Hassan, H., Hatokova, Z., Hausenloy, D. J., Heales, S. J., Heiestad, C., Hellgren, K. T., Henrique, A., Hepple, R. T., Hernansanz-Agustin, P., Hewakapuge, S., Hickey, A. J., Ho, D. H., Hoehn, K. L., Hoel, F., Holland, O. J., Holloway, G. P., Holzner, L., Hoppel, C. L., Hoppeler, H., Hoppel, F., Houstek, J., Huete-Ortega, M., Hyrossova, P., Iglesias-Gonzalez, J., Indiveri, C., Irving, B. A., Isola, R., Iyer, S., Jackson, C. B., Jadiya, P., Jana, P. F., Jandeleit-Dahm, K., Jang, D. H., Jang, Y. C., Janowska, J., Jansen, K., Jansen-Duerr, P., Jansone, B., Jarmuszkiewicz, W., Jaskiewicz, A., Jaspers, R. T., Jedlicka, J., Jerome, E., Jespersen, N. R., Jha, R. K., Joseph, V., Juhasz, L., Jurczak, M. J., Jurk, D., Kaambre, T., Kaczor, J. J., Kainulainen, H., Kampa, R. P., Kandel, S. M., Kane, D. A., Kapferer, W., Kapnick, S., Kappler, L., Karabatsiakis, A., Karavaeva, I., Karkucinska-Wieckowska, A., Kaur, S., Keijer, J., Keller, M. A., Keppner, G., Khamoui, A. V., Kidere, D., Kilbaugh, T., Kim, H. K., Kim, J. K., Kimoloi, S., Klepinin, A., Klepinina, L., Klingenspor, M., Klocker, H., Komlódi, T., Kolasa, I., Koopman, W. J., Kopitar-Jerala, N., Kowaltowski, A. J., Kozlov, A. V., Krajcova, A., Krako Jakovljevic, N., Kristal, B. S., Krycer, J. R., Kuang, J., Kucera, O., Kuka, J., Kwak, H. B., Kwast, K., Kwon, O. S., Laasmaa, M., Labieniec-Watala, M., Lai, N., Lalic, N. 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• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Bioenergetic Communications
• Publisher: Oroboros Ecosystem
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Bioenergetic Communications 2020:1
• Publisher Policy: Reproduced under a Creative Commons License