Smith, G., Wood, A., White, I., Pell, J., Cameron, A. and Dobbie, R. (2004) Neonatal respiratory morbidity at term and the risk of childhood asthma. Archives of Disease in Childhood, 89(10), pp. 956-960. (doi: 10.1136/adc.2003.045971)
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Abstract
Objective: To determine whether neonatal respiratory morbidity at term is associated with an increased risk of later asthma and whether this may explain previously described associations between caesarean delivery and asthma. Design: Retrospective cohort study using Scottish Morbidity Record (SMR) data of maternity (SMR02), neonatal (SMR11), and acute hospital (SMR01) discharges. Setting: Scotland. Participants: All singleton births at term between 1992 - 1995 in 23 Scottish maternity hospitals. Main outcome measures: Hospital admission with a diagnosis of asthma in the principal position between 1992 and 2000. Results: Children who had a diagnosis of transient tachypnoea of the newborn or respiratory distress syndrome were at increased risk of being admitted to hospital with a diagnosis of asthma ( hazard ratio (HR) 1.7, 95% confidence interval ( 95% CI) 1.4 to 2.2, p< 0.001). This association was observed both among children delivered vaginally ( HR 1.5, 95% CI 1.1 to 2.0, p = 0.007) and among those delivered by caesarean section ( HR 2.2, 95% CI 1.6 to 3.0, p< 0.001). In the absence of neonatal respiratory morbidity, delivery by caesarean section was weakly associated with the risk of asthma in childhood ( HR 1.1, 95% CI 1.0 to 1.2, p = 0.004). The strengths of the associations were similar whether the caesarean delivery was planned or emergency and were not significantly altered by adjustment for maternal, obstetric, and other neonatal characteristics. Conclusions: Neonatal respiratory morbidity at term is associated with an increased risk of asthma in childhood which may explain previously described associations between caesarean delivery and later asthma.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cameron, Professor Alan and Pell, Professor Jill |
Authors: | Smith, G., Wood, A., White, I., Pell, J., Cameron, A., and Dobbie, R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Centre for Population and Health Sciences |
Journal Name: | Archives of Disease in Childhood |
Journal Abbr.: | Arch. Dis. Child. |
Publisher: | B M J Group |
ISSN: | 0003-9888 |
ISSN (Online): | 1468-2044 |
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