Pulmonary hypertension

MacLean, M.R., Church, C., MacKenzie, A., Jayasekera, G. and Mair, K. (2019) Pulmonary hypertension. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 439-447. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_41)

Abstract

Pulmonary arterial hypertension (PAH) is defined by a resting mean pulmonary artery pressure (PAP) >25 mm Hg, pulmonary vascular resistance (PVR) >3 Wood units, and pulmonary capillary wedge pressure <15 mm Hg (in the absence of other causes of PH). There are five categories of pulmonary hypertension (PH) in the latest World Health Organization classification (Simonneau G, Robbins IM, Beghetti M, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S43–54): (1) PAH (including heritable PAH and idiopathic PAH formally known as primary pulmonary hypertension (PPH)); (2) PH due to left heart disease; (3) PH due to lung diseases and/or hypoxia; (4) chronic thromboembolic PH (CTEPH); and (5) PH with unclear multifactorial mechanisms. The mortality rate of PAH remains high despite current treatment (Hoeper and Simon, Eur Respir Rev 23(134):450–457, 2014). Here we will review PAH, current knowledge of treatments, and evolving therapeutic approaches.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Mair, Dr Kirsty and MacLean, Professor Margaret and Jayasekera, Dr Geeshath
• Authors: MacLean, M.R., Church, C., MacKenzie, A., Jayasekera, G., and Mair, K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Publisher: Springer
• ISBN: 9783030164805
• Published Online: 03 August 2019