Microparticles and exosomes in cell-cell communication

Rios, F. J. , Touyz, R. M. , Montezano, A. C. and Burger, D. (2019) Microparticles and exosomes in cell-cell communication. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 159-168. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_15)

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Growing evidence indicates that cells are able to communicate with neighbouring and distant cells in the body by production of extracellular vesicles (EV). EV are classified according to their size and mechanisms of formation. Exosomes and microparticles are the most extensively studied clinically relevant forms of EV, and they often reflect the activation status of the parent cell, by carrying similar surface markers and cargo. Because of these molecular characteristics, EV are considered to be mediators of cell activation by transferring molecules (e.g., proteins, lipids, and nucleic acids) to neighbouring or distant cell populations. Increased levels of circulating EV have been observed in various diseases, including hypertension, atherosclerosis, kidney diseases, and cancer. In this chapter, we will address the formation of different EV and their importance in cell-cell communication, controlling basic cellular functions in homeostatic and pathologic conditions associated with cardiovascular diseases. In addition, we highlight their role as biomarkers and discuss the potential of EV as therapeutic tools.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Rios, Dr Francisco and Montezano, Dr Augusto and Touyz, Professor Rhian
Authors: Rios, F. J., Touyz, R. M., Montezano, A. C., and Burger, D.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Published Online:03 August 2019

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