Vascular signaling

Neves, K. B. and Touyz, R. M. (2019) Vascular signaling. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 83-91. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_8)

Abstract

The vascular system is a highly complex and well-organized system in which signal transduction plays critical physiological and pathophysiological roles. The vasculature is equipped with numerous receptors and complex intracellular signaling molecules and networks that drive appropriate responses to extracellular stimuli. Understanding mechanisms whereby extracellular stimuli modulate vascular cell function in health and disease will facilitate discovery and development of new disease-targeted therapies. To date most classical drugs exert effects by inhibiting cell membrane receptors. In this chapter we describe some of the major intracellular signaling systems in vascular smooth muscle cells (VSMCs) with particular emphasis on the role of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs).

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Touyz, Professor Rhian and Neves, Dr Karla
• Authors: Neves, K. B., and Touyz, R. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Publisher: Springer
• ISBN: 9783030164805
• Published Online: 03 August 2019