Phillips, D. , Brodie, G., Memarzadeh, S., Tang, G. L. and France, D. J. (2020) MIDA boronate allylation – synthesis of ibuprofen. RSC Advances, 10(51), pp. 30624-30630. (doi: 10.1039/D0RA03338C)
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Abstract
MIDA boronates are among the most useful reagents for the Suzuki–Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, including a new synthesis of the well-known COX inhibitor ibuprofen.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Memarzadeh, Ms Sarah and Brodie, Mr Glen and France, Dr David and Phillips, Mr David |
| Authors: | Phillips, D., Brodie, G., Memarzadeh, S., Tang, G. L., and France, D. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | RSC Advances |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2046-2069 |
| ISSN (Online): | 2046-2069 |
| Published Online: | 18 August 2020 |
| Copyright Holders: | Copyright © 2020 The Royal Society of Chemistry |
| First Published: | First published in RSC Advances 10(51): 20624-30630 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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