Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Bravi, F. et al. (2021) Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer. Oral Diseases, 27(1), pp. 73-93. (doi: 10.1111/odi.13502) (PMID:32569410)

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Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.

Item Type:Articles
Additional Information:National Institutes of Health (NIH), Grant/Award Number: P01CA068384, K07CA104231, R01CA048996, R01DE012609, TW001500, R01CA061188, P01CA068384, K07CA104231, R01DE013158, P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667, R01CA078609, R01CA100679, R01CA051845, R01CA030022 and DE016631 and the Intramural Research Program; National Cancer Institute (NCI), Grant/Award Number: R03CA113157 and R01- CA90731 and the Intramural Research Program; National Institute of Dental and Craniofacial Research (NIDCR), Grant/Award Number: R03DE016611, R01DE011979 and R01DE013110; Italian Association for Research on Cancer (AIRC), Grant/Award Number: 10068; Italian League against Cancer; Italian Ministry of Research; The Swiss Research against cancer/Oncosuisse, Grant/Award Number: KFS-700, OCS-1633 and KFS1096-09-2000; European Commission, Grant/ Award Number: IC18-CT97-0222 and IC15- CT98-0332; Veterans Affairs Merit Review Funds; National Institute of Environmental Health Sciences (NIEHS), Grant/Award Number: P30ES010126 and P30ES010126; Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center; Fondo para la Investigacion Cientifica y Tecnologica Argentina (FONCYT); Institut Hospital del Mar d’Investigacions Mediquès (IMIM); Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP), Grant/ Award Number: 01/01768-2, GENCAPO 04/12054-9 and 10/51168-0; Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government, Grant/Award Number: FIS 97/0024, FIS 97/0662 and BAE 01/5013; International Union Against Cancer (UICC); Yamagiwa-Yoshida Memorial International Cancer Study Grant; European Community (5th Framework Programme), Grant/Award Number: QLK1- CT-2001-00182; Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan, Grant/Award Number: 17015052; Third- Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan, Grant/Award Number: H20-002; Italian Foundation for Cancer Research (FIRC); Italian Ministry of Education, Grant/Award Number: X8YCBN; Fribourg League against Cancer, Grant/Award Number: FOR381.88; Swiss Cancer Research, Grant/Award Number: AKT 617; Gustave-Roussy Institute, Grant/ Award Number: 88D28; French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Institute for Public Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); Fondation de France, Grant/Award Number: 01GB9702/3; Fondation ARC pour la Recherche sur le Cancer; French Ministry of Labour; French Ministry of Health; World Cancer Research Fund; Ministry of Science, Research and Arts Baden-Wurttemberg; German Ministry of Education and Research; Johns Hopkins Richard Gelb Cancer Prevention Award; Università degli Studi di Milano: "Young Investigator Grant Program 2017" to Valeria Edefonti
Glasgow Author(s) Enlighten ID:Conway, Professor David
Creator Roles:
Conway, D.Funding acquisition, Resources, Supervision, Writing – review and editing
Authors: Bravi, F., Lee, Y.‐C. A., Hashibe, M., Boffetta, P., Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, S., Brennan, P., Brenner, H., Cadoni, G., Canova, C., Chen, C., Chuang, S.‐C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, P., Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., McClean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, E., Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoï, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Świątkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch‐Filho, V., Yu, G.‐P., Zevallos, J. P., Zhang, Z.‐F., Zheng, T., and Znaor, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Oral Diseases
ISSN (Online):1601-0825
Published Online:22 June 2020
Copyright Holders:Copyright © 2020 John Wiley & Sons, Inc.
First Published:First published in Oral Diseases 27(1): 73-93
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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