McGlynn, E., Nabaei, V. , Ren, E., Galeote-Checa, G., Das, R. , Curia, G. and Heidari, H. (2021) The future of neuroscience: flexible and wireless implantable neural electronics. Advanced Science, 8(10), 2002693. (doi: 10.1002/advs.202002693) (PMCID:PMC8132070)
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Abstract
Neurological diseases are a prevalent cause of global mortality and are of growing concern when considering an ageing global population. Traditional treatments are accompanied by serious side effects including repeated treatment sessions, invasive surgeries, or infections. For example, in the case of deep brain stimulation, large, stiff, and battery powered neural probes recruit thousands of neurons with each pulse, and can invoke a vigorous immune response. This paper presents challenges in engineering and neuroscience in developing miniaturized and biointegrated alternatives, in the form of microelectrode probes. Progress in design and topology of neural implants has shifted the goal post toward highly specific recording and stimulation, targeting small groups of neurons and reducing the foreign body response with biomimetic design principles. Implantable device design recommendations, fabrication techniques, and clinical evaluation of the impact flexible, integrated probes will have on the treatment of neurological disorders are provided in this report. The choice of biocompatible material dictates fabrication techniques as novel methods reduce the complexity of manufacture. Wireless power, the final hurdle to truly implantable neural interfaces, is discussed. These aspects are the driving force behind continued research: significant breakthroughs in any one of these areas will revolutionize the treatment of neurological disorders.
Item Type: | Articles |
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Additional Information: | This work was supported by the EU H2020 FET Proactive RIA project Hybrid Enhanced Regenerative Medicine Systems (HERMES, GA n.824164). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McGlynn, Eve and Nabaei, Dr Vahid and Heidari, Professor Hadi and Das, Dr Rupam |
Authors: | McGlynn, E., Nabaei, V., Ren, E., Galeote-Checa, G., Das, R., Curia, G., and Heidari, H. |
College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
Journal Name: | Advanced Science |
Publisher: | Wiley |
ISSN: | 2198-3844 |
ISSN (Online): | 2198-3844 |
Published Online: | 09 March 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Advanced Science 8(10): 2002693 |
Publisher Policy: | Reproduced under a Creative Commons License |
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