Telomere length behaves as biomarker of somatic redundancy rather than biological age

Boonekamp, J. J. , Simons, M. J. P., Hemerik, L. and Verhulst, S. (2013) Telomere length behaves as biomarker of somatic redundancy rather than biological age. Aging Cell, 12(2), pp. 330-332. (doi: 10.1111/acel.12050) (PMID:23346961)

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Biomarkers of aging are essential to predict mortality and aging‐related diseases. Paradoxically, age itself imposes a limitation on the use of known biomarkers of aging because their associations with mortality generally diminish with age. How this pattern arises is, however, not understood. With meta‐analysis we show that human leucocyte telomere length (TL ) predicts mortality, and that this mortality association diminishes with age, as found for other biomarkers of aging. Subsequently, we demonstrate with simulation models that this observation cannot be reconciled with the popular hypothesis that TL is proportional to biological age. Using the reliability theory of aging, we instead propose that TL is a biomarker of somatic redundancy, the body's capacity to absorb damage, which fits the observed pattern well. We discuss to what extent diminishing redundancy with age may also explain the observed diminishing mortality modulation with age of other biomarkers of aging. Considering diminishing somatic redundancy as the causal agent of aging may critically advance our understanding of the aging process, and improve predictions of life expectancy and vulnerability to aging‐related diseases.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Boonekamp, Dr Jelle
Authors: Boonekamp, J. J., Simons, M. J. P., Hemerik, L., and Verhulst, S.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Aging Cell
ISSN (Online):1474-9726
Published Online:24 January 2013

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