Chen, S., Paterson, G. K., Tong, H. H., Mitchell, T. J. and DeMaria, T. F. (2005) Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. FEMS Microbiology Letters, 253(1), pp. 151-154. (doi: 10.1016/j.femsle.2005.09.052)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1016/j.femsle.2005.09.052
Abstract
Sortase A (SrtA) is required to anchor neuraminidase, β-galactosidase, and possibly other LPXTG motif proteins to the pneumococcal cell surface. We examined the role of SrtA in Streptococcus pneumoniae nasopharyngeal (NP) colonization in the chinchilla model. The srtA mutant colonized the nasopharynx at a significantly lower level than the D39 parent strain during the second and third week of the carriage, and was eliminated from nasopharynx one week earlier than the D39 pneumococci. Our data indicate that SrtA contributes to pneumococcal NP colonization in this animal model.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mitchell, Professor Timothy |
| Authors: | Chen, S., Paterson, G. K., Tong, H. H., Mitchell, T. J., and DeMaria, T. F. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | FEMS Microbiology Letters |
| Publisher: | Wiley |
| ISSN: | 0378-1097 |
| ISSN (Online): | 1574-6968 |
| Published Online: | 09 January 2006 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric