McBride, M.W. , Charchar, F.J., Graham, D. , Miller, W.H. , Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi: 10.1113/jphysiol.2003.049361)
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Publisher's URL: http://dx.doi.org/10.1113/jphysiol.2003.049361
Abstract
Inbred strains of rodents have been used to study mammalian physiology and pathophysiology in an attempt to understand the contribution of genes in the pathogenesis of the disease process. In this review we focus on experimental animal models to identify quantitative trait loci (QTL) and possible strategies for identifying underlying genetic determinants responsible for hypertension. Confirmation of the existence of the QTL and dissection of the implicated region can be undertaken by production of either recombinant inbred, consomic or congenic strains. Despite complex interactions and the relatively few confirmed causative genes underlying QTL, recent developments in rat genome resources and advancement in statistical and bioinformatic methods will facilitate the identification of major gene(s) responsible for complex, polygenic traits.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Graham, Dr Delyth and McBride, Dr Martin and Dominiczak, Professor Anna and Miller, Dr William |
| Authors: | McBride, M.W., Charchar, F.J., Graham, D., Miller, W.H., Strahorn, P., Carr, F.J., and Dominiczak, A.F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Physiology |
| ISSN: | 0022-3751 |
| ISSN (Online): | 1469-7793 |
| Published Online: | 17 October 2003 |
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