Development of perioperative care for pigs undergoing laryngeal transplantation: a case series

Murison, P.J. , Jones, A., Mitchard, L., Burt, R. and Birchall, M.A. (2009) Development of perioperative care for pigs undergoing laryngeal transplantation: a case series. Laboratory Animals, 43(4), pp. 338-343. (doi: 10.1258/la.2009.008101) (PMID:19535394)

Abstract

Pigs are ideal animal models for airway surgical research, facilitating the successful translation of science into clinical practice. Despite their ubiquitous use, there is a paucity of information on the perioperative care of pigs, especially for major procedures. In a series of experiments to investigate laryngeal transplantation, we combined veterinary and medical experience to develop protocols for perioperative management of pigs, including high dependency care. Novel airway management methods were developed. A pain scoring system was used to direct analgesia use. Fluid balance and electrolytes were monitored closely. Recent animals received a central venous line via the femoral vein two days prior to transplantation to facilitate blood sampling and drug delivery. Intensive monitoring and airway management were required to ensure a successful outcome. Methods for optimal perioperative care are proposed. These results will help future groups wishing to use pigs in airway research, will reduce numbers of animals used and improve animal welfare.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Murison, Professor Pamela
• Authors: Murison, P.J., Jones, A., Mitchard, L., Burt, R., and Birchall, M.A.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Laboratory Animals
• ISSN: 0023-6772
• ISSN (Online): 1758-1117
• Published Online: 01 October 2009