Extracellular vesicles: new targets for vaccines against helminth parasites

Drurey, C. , Coakley, G. and Maizels, R. M. (2020) Extracellular vesicles: new targets for vaccines against helminth parasites. International Journal for Parasitology, 50(9), pp. 623-633. (doi: 10.1016/j.ijpara.2020.04.011) (PMID:32659278)

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The hunt for effective vaccines against the major helminth diseases of humans has yet to bear fruit despite much effort over several decades. No individual parasite antigen has proved to elicit full protective immunity, suggesting that combinatorial strategies may be required. Recently it has been discovered that extracellular vesicles released by parasitic helminths contain multiple potential immune modulators, which could together be targeted by a future vaccine. Increasing knowledge of helminth extracellular vesicle components, both enclosed by and exposed on the membrane, will open up a new field of targets for an effective vaccine. This review discusses the interactions between helminth extracellular vesicles and the immune system discovered thus far, and the advantages of targeting these lipid-bound packages with a vaccine. In addition, we also comment upon specific antigens that may be the best targets for an anti-helminth vaccine. In the future, extensive knowledge of the parasites' full arsenal in controlling their host may finally provide us with the ideal target for a fully effective vaccine.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Coakley, Miss Gillian and Drurey, Claire and Maizels, Professor Rick
Authors: Drurey, C., Coakley, G., and Maizels, R. M.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Research Centre:College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
Journal Name:International Journal for Parasitology
ISSN (Online):1879-0135
Published Online:11 July 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in International Journal for Parasitology 50(9):623-633
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173801Helminths and the Immune System: Regulation, Regulators and ImmunityRichard MaizelsWellcome Trust (WELLCOTR)106122/A/14/ZInstitute of Infection, Immunity & Inflammation
170547The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/ZRIII - Parasitology