Drurey, C. , Coakley, G. and Maizels, R. M. (2020) Extracellular vesicles: new targets for vaccines against helminth parasites. International Journal for Parasitology, 50(9), pp. 623-633. (doi: 10.1016/j.ijpara.2020.04.011) (PMID:32659278)
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Abstract
The hunt for effective vaccines against the major helminth diseases of humans has yet to bear fruit despite much effort over several decades. No individual parasite antigen has proved to elicit full protective immunity, suggesting that combinatorial strategies may be required. Recently it has been discovered that extracellular vesicles released by parasitic helminths contain multiple potential immune modulators, which could together be targeted by a future vaccine. Increasing knowledge of helminth extracellular vesicle components, both enclosed by and exposed on the membrane, will open up a new field of targets for an effective vaccine. This review discusses the interactions between helminth extracellular vesicles and the immune system discovered thus far, and the advantages of targeting these lipid-bound packages with a vaccine. In addition, we also comment upon specific antigens that may be the best targets for an anti-helminth vaccine. In the future, extensive knowledge of the parasites' full arsenal in controlling their host may finally provide us with the ideal target for a fully effective vaccine.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Coakley, Miss Gillian and Drurey, Claire and Maizels, Professor Rick |
| Authors: | Drurey, C., Coakley, G., and Maizels, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | International Journal for Parasitology |
| Publisher: | Elsevier |
| ISSN: | 0020-7519 |
| ISSN (Online): | 1879-0135 |
| Published Online: | 11 July 2020 |
| Copyright Holders: | Copyright © 2020 The Authors |
| First Published: | First published in International Journal for Parasitology 50(9):623-633 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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