Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome

Formenti, F., Chen, R., McPeak, H., Murison, P.J. , Matejovic, M., Hahn, C.E.W. and Farmery, A.D. (2015) Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome. British Journal of Anaesthesia, 114(4), pp. 683-688. (doi: 10.1093/bja/aeu407) (PMID:25631471) (PMCID:PMC4364062)

Abstract

BACKGROUND:There is considerable interest in oxygen partial pressure (Po2) monitoring in physiology, and in tracking Po2 changes dynamically when it varies rapidly. For example, arterial Po2 ([Formula: see text]) can vary within the respiratory cycle in cyclical atelectasis (CA), where [Formula: see text] is thought to increase and decrease during inspiration and expiration, respectively. A sensor that detects these [Formula: see text] oscillations could become a useful diagnostic tool of CA during acute respiratory distress syndrome (ARDS). METHODS:We developed a fibreoptic Po2 sensor (<200 µm diameter), suitable for human use, that has a fast response time, and can measure Po2 continuously in blood. By altering the inspired fraction of oxygen ([Formula: see text]) from 21 to 100% in four healthy animal models, we determined the linearity of the sensor's signal over a wide range of [Formula: see text] values in vivo. We also hypothesized that the sensor could measure rapid intra-breath [Formula: see text] oscillations in a large animal model of ARDS. RESULTS:In the healthy animal models, [Formula: see text] responses to changes in [Formula: see text] were in agreement with conventional intermittent blood-gas analysis (n=39) for a wide range of [Formula: see text] values, from 10 to 73 kPa. In the animal lavage model of CA, the sensor detected [Formula: see text] oscillations, also at clinically relevant [Formula: see text] levels close to 9 kPa. CONCLUSIONS:We conclude that these fibreoptic [Formula: see text] sensors have the potential to become a diagnostic tool for CA in ARDS.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Murison, Professor Pamela
• Authors: Formenti, F., Chen, R., McPeak, H., Murison, P.J., Matejovic, M., Hahn, C.E.W., and Farmery, A.D.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: British Journal of Anaesthesia
• Publisher: Elsevier
• ISSN: 0007-0912
• ISSN (Online): 1471-6771
• Copyright Holders: Copyright © 2015 The Author(s)
• First Published: First published in British Journal of Anaesthesia 114(4):683-688
• Publisher Policy: Reproduced under a Creative Commons License