A short peptide that preferentially binds c-MYC G-quadruplex DNA

Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G. and Di Antonio, M. (2020) A short peptide that preferentially binds c-MYC G-quadruplex DNA. Chemical Communications, 56(63), pp. 8940-8943. (doi: 10.1039/D0CC02954H) (PMID:32638724)

Abstract

G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ~700,000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and antiparallel G4s tested.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Morgan, Dr Danielle and Jamieson, Professor Andrew
• Authors: Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G., and Di Antonio, M.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Chemical Communications
• Publisher: Royal Society of Chemistry
• ISSN: 1359-7345
• ISSN (Online): 1364-548X
• Published Online: 01 July 2020
• Copyright Holders: Copyright © 2020 The Royal Society of Chemistry
• First Published: First published in Chemical Communications 56(63): 8940-8943
• Publisher Policy: Reproduced under a Creative Commons licence