The new (dis)order in RNA regulation

Järvelin, A. I., Noerenberg, M., Davis, I. and Castello, A. (2016) The new (dis)order in RNA regulation. Cell Communication and Signaling, 14, 9. (doi: 10.1186/s12964-016-0132-3) (PMID:27048167) (PMCID:PMC4822317)

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RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RNA-binding domains that form stable secondary and tertiary structures. However, a number of pioneering studies over the past decades, together with recent proteome-wide data, have challenged this view, revealing surprising roles for intrinsically disordered protein regions in RNA binding. Here, we discuss how disordered protein regions can mediate protein-RNA interactions, conceptually grouping these regions into RS-rich, RG-rich, and other basic sequences, that can mediate both specific and non-specific interactions with RNA. Disordered regions can also influence RNA metabolism through protein aggregation and hydrogel formation. Importantly, protein-RNA interactions mediated by disordered regions can influence nearly all aspects of co- and post-transcriptional RNA processes and, consequently, their disruption can cause disease. Despite growing interest in disordered protein regions and their roles in RNA biology, their mechanisms of binding, regulation, and physiological consequences remain poorly understood. In the coming years, the study of these unorthodox interactions will yield important insights into RNA regulation in cellular homeostasis and disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Castello, Professor Alfredo
Authors: Järvelin, A. I., Noerenberg, M., Davis, I., and Castello, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Cell Communication and Signaling
Publisher:BioMed Central
ISSN (Online):1478-811X
Copyright Holders:Copyright © 2016 Järvelin et al.
First Published:First published in Cell Communication and Signaling 14: 9
Publisher Policy:Reproduced under a Creative Commons License

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