A brave new world of RNA-binding proteins

Hentze, M. W., Castello, A. , Schwarzl, T. and Preiss, T. (2018) A brave new world of RNA-binding proteins. Nature Reviews Molecular Cell Biology, 19(5), pp. 327-341. (doi: 10.1038/nrm.2017.130) (PMID:29339797)

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RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the bound RNAs. Several hundred such RBPs have been discovered and investigated over the years. Recent proteome-wide studies have more than doubled the number of proteins implicated in RNA binding and uncovered hundreds of additional RBPs lacking conventional RBDs. In this Review, we discuss these new RBPs and the emerging understanding of their unexpected modes of RNA binding, which can be mediated by intrinsically disordered regions, protein–protein interaction interfaces and enzymatic cores, among others. We also discuss the RNA targets and molecular and cellular functions of the new RBPs, as well as the possibility that some RBPs may be regulated by RNA rather than regulate RNA.

Item Type:Articles
Additional Information:The authors also acknowledge research funding from the European Research Council (ERC-2011-ADG_20110310; M.W.H.), a UK Medical Research Council Career Development Award (MR/L019434/1; A.C), the European Molecular Biology Laboratory Interdisciplinary Postdoctoral 2 Programme (EIPOD2/291772; T.S.) and the Australian National Health and Medical Research Council (APP1120483; M.W.H. and T.P.).
Glasgow Author(s) Enlighten ID:Castello, Professor Alfredo
Authors: Hentze, M. W., Castello, A., Schwarzl, T., and Preiss, T.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Nature Reviews Molecular Cell Biology
Publisher:Nature Research
ISSN (Online):1471-0080
Published Online:17 January 2018
Copyright Holders:Copyright © 2018 Macmillan Publishers Limited, part of Springer Nature
First Published:First published in Nature Reviews Molecular Cell Biology 19(5): 327-341
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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