Terradas-Terradas, M. , Robertson, N. A., Chandra, T. and Kirschner, K. (2020) Clonality in haematopoietic stem cell ageing. Mechanisms of Ageing and Development, 189, 111279. (doi: 10.1016/j.mad.2020.111279) (PMID:32526214) (PMCID:PMC7347006)
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Abstract
Clonal haematopoiesis of indeterminate potential (CHIP) is widespread in the elderly. CHIP is driven by somatic mutations in leukaemia driver genes, such as Janus Kinase 2 (JAK2), Tet methylcytosine dioxygenase 2 (TET2), ASXL Transcriptional Regulator 1 (ASXL1) and DNA (cytosine-5)-methyltransferase 3A (DNMT3A), leading to reduced diversity of the blood pool. CHIP carries an increased risk for leukaemia and cardiovascular disease. Apart from mutations driving CHIP, environmental factors such as chemokines and cytokines have been implicated in age-dependent multimorbidities associated with CHIP. However, the mechanism of CHIP onset and the relationship with environmental and cell-intrinsic factors remain poorly understood. Here we contrast cell-intrinsic and environmental factors involved in CHIP development and disease propagation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Terradas Terradas, Maria and Kirschner, Dr Kristina and Robertson, Mr Neil |
Authors: | Terradas-Terradas, M., Robertson, N. A., Chandra, T., and Kirschner, K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Mechanisms of Ageing and Development |
Publisher: | Elsevier |
ISSN: | 0047-6374 |
ISSN (Online): | 1872-6216 |
Published Online: | 08 June 2020 |
Copyright Holders: | Copyright © 2020 The Authors |
First Published: | First published in Mechanisms of Ageing and Development 189: 111279 |
Publisher Policy: | Reproduced under a Creative Commons License |
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