Data Study Group Final Report: Roche

Abdollahyan, M. et al. (2020) Data Study Group Final Report: Roche. Project Report. Alan Turing Institute. (doi: 10.5281/zenodo.3876989).

Abstract

Data Study Groups are week-long events at The Alan Turing Institute bringing together some of the country’s top talent from data science, artificial intelligence, and wider fields, to analyse real-world data science challenges. Roche: Personalised lung cancer treatment modelling using electronic health records and genomics Cancer immunotherapy (CIT) is a promising new type of cancer treatment that uses the patient’s own immune system to fight cancer cells. CIT drugs work to stop the cancer cells from turning off the immune system’s T-cells by inhibiting the PD-L1 produced by the tumour cells (PD-L1 is a protein that binds to PD-1 receptors on T-cells and prevents the immune system from attacking the cancer cells). CIT is currently being used to treat patients with non-small cell lung cancer (NSCLC) for whom chemotherapy or other drugs have failed. CIT is also be-ing used as part of the first-line treatment in patients with advanced NSCLC (aNSCLC - stage III and higher). Theoretically, patients with high PD-L1 ex-pression levels are more likely to respond well to CIT; however, in practice, patient outcomes vary considerably. In this data study group, we investigated different approaches for predicting survival time for patients treated with CIT as first line of treatment, using both electronic health records and tumour genomic data. We also investigated the causal effects of CIT vs other oncology treatments, and studied treatment heterogeneity. The results contribute to identifying patients who are most likely to benefit from CIT.

• Item Type: Research Reports or Papers (Project Report)
• Additional Information: This work was supported by The Alan Turing Institute under the EPSRC grant EP/N510129/1.
• Status: Published
• Glasgow Author(s) Enlighten ID: Swallow, Dr Ben
• Authors: Abdollahyan, M., Bica, I., Buchholz, A., Conde, S., Cunningham, N., Dennis, J., DiazOrdaz, K., Grimm, F., Ilieva, S., Kiraly, F., Li, C., Liao, W., Mossotto, E., Page, H., Parreno-Centeno, M., and Swallow, B.
• College/School: College of Science and Engineering > School of Mathematics and Statistics > Statistics
• Publisher: Alan Turing Institute
• Copyright Holders: Copyright © 2020 The Authors
• Publisher Policy: Reproduced under a Creative Commons License