Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study

Jamal-Hanjani, M. et al. (2014) Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study. PLoS Biology, 12(7), e1001906. (doi: 10.1371/journal.pbio.1001906) (PMID:25003521) (PMCID:PMC4086714)

Abstract

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Le Quesne, Professor John
• Authors: Jamal-Hanjani, M., Hackshaw, A., Ngai, Y., Shaw, J., Dive, C., Quezada, S., Middleton, G., de Bruin, E., Le Quesne, J., Shafi, S., Falzon, M., Horswell, S., Blackhall, F., Khan, I., Janes, S., Nicolson, M., Lawrence, D., Forster, M., Fennell, D., Lee, S.-M., Lester, J., Kerr, K., Muller, S., Iles, N., Smith, S., Murugaesu, N., Mitter, R., Salm, M., Stuart, A., Matthews, N., Adams, H., Ahmad, T., Attanoos, R., Bennett, J., Birkbak, N. J., Booton, R., Brady, G., Buchan, K., Capitano, A., Chetty, M., Cobbold, M., Crosbie, P., Davies, H., Denison, A., Djearman, M., Goldman, J., Haswell, T., Joseph, L., Kornaszewska, M., Krebs, M., Langman, G., MacKenzie, M., Millar, J., Morgan, B., Naidu, B., Nonaka, D., Peggs, K., Pritchard, C., Remmen, H., Rowan, A., Shah, R., Smith, E., Summers, Y., Taylor, M., Veeriah, S., Waller, D., Wilcox, B., Wilcox, M., Woolhouse, I., McGranahan, N., and Swanton, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: PLoS Biology
• Publisher: Public Library of Science
• ISSN: 1544-9173
• ISSN (Online): 1545-7885
• Copyright Holders: Copyright: 2014 Jamal-Hanjani et al.
• First Published: First published in PLoS Biology 12(7):e1001906
• Publisher Policy: Reproduced under a Creative Commons licence