Drug screening using model systems: some basics

Cagan, R. (2016) Drug screening using model systems: some basics. Disease Models and Mechanisms, 9(11), pp. 1241-1244. (doi: 10.1242/dmm.028159) (PMID:27821602) (PMCID:PMC5117237)

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An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical space' and 'druggability' are all concepts worth exploring when deciding which screening path to take. I discuss some of the lessons I learned that may be useful as you navigate the screening matrix.

Item Type:Articles (Editorial)
Glasgow Author(s) Enlighten ID:Cagan, Professor Ross
Authors: Cagan, R.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Disease Models and Mechanisms
Publisher:The Company of Biologists Ltd.
ISSN (Online):1754-8411
Copyright Holders:Copyright © 2016
First Published:First published in Disease Models and Mechanisms 9:1241-1244
Publisher Policy:Reproduced under a Creative Commons licence

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