Controlled transdermal release of antioxidant ferulate by a porous Sc(III) MOF

Osorio-Toribio, G. et al. (2020) Controlled transdermal release of antioxidant ferulate by a porous Sc(III) MOF. iScience, 23(6), 101156. (doi: 10.1016/j.isci.2020.101156) (PMID:32450520) (PMCID:PMC7251947)

Abstract

The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Forgan, Professor Ross
• Authors: Osorio-Toribio, G., Velásquez-Hernández, M. d. J., Mileo, P. G.M., Zárate, J. A., Aguila-Rosas, J., Leyva-Gómez, G., Sánchez-Sánchez, R., Magaña, J. J., Pérez-Díaz, M. A., Lázaro, I. A., Forgan, R. S., Maurin, G., Lima, E., and Ibarra, I. A.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: iScience
• Publisher: Elsevier (Cell Press)
• ISSN: 2589-0042
• ISSN (Online): 2589-0042
• Published Online: 11 May 2020
• Copyright Holders: Crown Copyright © 2020
• First Published: First published in iScience 23(6):101156
• Publisher Policy: Reproduced under a Creative Commons licence