Controlled transdermal release of antioxidant ferulate by a porous Sc(III) MOF

Osorio-Toribio, G. et al. (2020) Controlled transdermal release of antioxidant ferulate by a porous Sc(III) MOF. iScience, 23(6), 101156. (doi: 10.1016/j.isci.2020.101156) (PMID:32450520) (PMCID:PMC7251947)

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The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs).

Item Type:Articles
Glasgow Author(s) Enlighten ID:Forgan, Professor Ross
Authors: Osorio-Toribio, G., Velásquez-Hernández, M. d. J., Mileo, P. G.M., Zárate, J. A., Aguila-Rosas, J., Leyva-Gómez, G., Sánchez-Sánchez, R., Magaña, J. J., Pérez-Díaz, M. A., Lázaro, I. A., Forgan, R. S., Maurin, G., Lima, E., and Ibarra, I. A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:iScience
Publisher:Elsevier (Cell Press)
ISSN (Online):2589-0042
Published Online:11 May 2020
Copyright Holders:Crown Copyright © 2020
First Published:First published in iScience 23(6):101156
Publisher Policy:Reproduced under a Creative Commons licence

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