Programming properties of transient hydrogels by an enzymatic reaction

Panja, S. , Bohacova, K., Dietrich, B. and Adams, D. J. (2020) Programming properties of transient hydrogels by an enzymatic reaction. Nanoscale, 12(24), pp. 12840-12848. (doi: 10.1039/D0NR03012K) (PMID:32515773)

Abstract

Supramolecular gels are usually stable in time as they are formed under thermodynamic equilibrium or at least in a deep well of a kinetically trapped state. However, artificial construction of kinetically controlled transient supramolecular gels is an interesting challenge. In these systems, usually a kinetically trapped transient aggregate is formed by active building blocks that leads to gelation; the gel then typically returns to the solution state. In this work, we show that such transient aggregation can occur by successive formation of two distinctly different kinetically controlled metastable states. Control over the first metastable state allows us to achieve significant control over the stability and properties of the second metastable state.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dietrich, Bart and Adams, Dave and Panja, Dr Santanu
• Authors: Panja, S., Bohacova, K., Dietrich, B., and Adams, D. J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Nanoscale
• Publisher: Royal Society of Chemistry
• ISSN: 2040-3364
• ISSN (Online): 2040-3372
• Published Online: 03 June 2020
• Copyright Holders: Copyright © 2020 The Royal Society of Chemistry
• First Published: First published in Nanoscale 12(24): 12840-12848
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
174004		Multicomponent Supramolecular Hydrogels	Dave Adams	Engineering and Physical Sciences Research Council (EPSRC)	EP/L021978/2	Chemistry