Spatiotemporal regulation of signaling: focus on T cell activation and the immunological synapse

Garcia Gonzalez, E. and Ismail, S. (2020) Spatiotemporal regulation of signaling: focus on T cell activation and the immunological synapse. International Journal of Molecular Sciences, 21(9), e3283. (doi: 10.3390/ijms21093283) (PMID:32384769) (PMCID:PMC7247333)

Abstract

In a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output. To temporally and spatially modulate signaling events, cells generate specialized functional domains with variable lifetime and size that concentrate signaling molecules, enhancing their transduction potential. The plasma membrane is a key in this regulation, as it constitutes a primary signaling hub that integrates signals within and across the membrane. Here, we examine some of the mechanisms that cells exhibit to spatiotemporally regulate signal transduction, focusing on the early events of T cell activation from triggering of T cell receptor to formation and maturation of the immunological synapse.

• Item Type: Articles
• Additional Information: Funding: This work was supported by Cancer Research UK (CRUK, core funding award A19257).
• Keywords: signal transduction, T cells, immunological synapse, membrane domains, diffusion barriers.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ismail, Dr Shehab and Garcia Gonzalez, Dr Esther
• Authors: Garcia Gonzalez, E., and Ismail, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: International Journal of Molecular Sciences
• Publisher: MDPI
• ISSN: 1661-6596
• ISSN (Online): 1422-0067
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in International Journal of Molecular Sciences 21(9):e3283
• Publisher Policy: Reproduced under a Creative Commons Licence