Aggregation and crosslinking of poly(N,N-dimethylacrylamide)-b-pullulan double hydrophilic block copolymers

Plucinski, A., Willersinn, J., Lira, R. B., Dimova, R. and Schmidt, B. V.K.J. (2020) Aggregation and crosslinking of poly(N,N-dimethylacrylamide)-b-pullulan double hydrophilic block copolymers. Macromolecular Chemistry and Physics, 221(13), 2000053. (doi: 10.1002/macp.202000053)

Abstract

The self‐assembly of polymers is a major topic in current polymer chemistry. In here, the self‐assembly of a pullulan based double hydrophilic block copolymer, namely pullulan‐b ‐poly(N,N ‐dimethylacrylamide)‐co ‐poly(diacetone acrylamide) (Pull‐b ‐(PDMA‐co ‐PDAAM)) is described. The hydrophilic block copolymer induces phase separation at high concentration in aqueous solution. Additionally, the block copolymer displays aggregates at lower concentration, which show a size dependence on concentration. In order to stabilize the aggregates, crosslinking via oxime formation is described, which enables preservation of aggregates at high dilution, in dialysis and in organic solvents. With adequate stability by crosslinking, double hydrophilic block copolymer (DHBC) aggregates open pathways for potential biomedical applications in the future.

• Item Type: Articles
• Additional Information: The authors thank the Max-Planck society and the Deutsche Forschungsgemeinschaft (DFG) (SCHM 3282/3-1) for funding.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Plucinski, Alexander and Schmidt, Dr Bernhard
• Authors: Plucinski, A., Willersinn, J., Lira, R. B., Dimova, R., and Schmidt, B. V.K.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Macromolecular Chemistry and Physics
• Publisher: Wiley-VCH Verlag GmbH & Co.
• ISSN: 1022-1352
• ISSN (Online): 1521-3935
• Published Online: 09 June 2020
• Copyright Holders: Copyright © 2020 The Authors.
• First Published: First published in Macromolecular Chemistry and Physics 221(13):2000053
• Publisher Policy: Reproduced under a Creative Commons licence