Drotar, M.E., Silva, S., Barone, E., Campbell, D., Tsimbouri, P. , Jurvansu, J., Bhatia, P., Klein, G. and Wilson, J.B. (2003) Epstein-Barr virus nuclear antigen-1 and Myc cooperate in lymphomagenesis. International Journal of Cancer, 106, pp. 388-395. (doi: 10.1002/ijc.11224) (PMID:12845679)
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Abstract
The lymphomagenic action of myc genes in conjunction with Epstein-Barr virus nuclear antigen-1 (EBNA-1) have been examined using transgenic mice in several separate tests. Synergy between Myc and EBNA-1 in lymphomagenesis was revealed in a cross breed study where co-expression of transgenic myc and EBNA-1 led to a tumor latency period reduced significantly in some crosses. In the resulting bitransgenic tumors, expression of the Eμ-myc genes was not affected by EBNA-1 expression. MoMLV was utilized as a transposon tag to activate cellular oncogenes by infection of EμEBNA-1 mice. Rearrangement at the c-myc locus in B cell tumors from these mice again suggests a cooperative action between myc and EBNA-1. Tumors arising in EμEBNA-1 mice typically showed a trisomy of chromosome 15, upon which the c-myc locus resides. Bitransgenic tumors (EBNA-1/c-myc) did not show trisomy 15. This raises the possibility that amplification of c-myc is factorial in the selection of trisomy 15 in these tumors. These data indicate that myc and EBNA-1 act cooperatively and are not redundant in lymphomagenesis. Expression of EBNA-1 by EBV may provide a selection pressure in addition to translocation of the c-myc locus in the genesis of endemic Burkitt's lymphoma (BL).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wilson, Professor Joanna and Drotar, Mr Mark and Tsimbouri, Dr Monica |
| Authors: | Drotar, M.E., Silva, S., Barone, E., Campbell, D., Tsimbouri, P., Jurvansu, J., Bhatia, P., Klein, G., and Wilson, J.B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | International Journal of Cancer |
| ISSN: | 0020-7136 |
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