Silva-Filho, J. L. , Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M. and Costa, F. T.M. (2020) Plasmodium vivax in hematopoietic niches: hidden and dangerous. Trends in Parasitology, 36(5), pp. 447-458. (doi: 10.1016/j.pt.2020.03.002) (PMID:32298632)
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Abstract
Estimation of Plasmodium vivax biomass based on circulating biomarkers indicates the existence of a predominant biomass outside of the circulation that is not captured by peripheral parasitemia, in particular in patients with complicated outcomes. A series of recent studies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite replication and the development of transmission stages. However, significant knowledge gaps remain in our understanding of host-parasite interactions, pathophysiology, and the implications for treatment and diagnosis of such a reservoir. Here, we discuss the current status of this emerging research field in the context of P. vivax.
| Item Type: | Articles |
|---|---|
| Additional Information: | S.C.W. is supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (award numbers U19AI089676 and R21AI142472), and the UK Medical Research Council (award number MR/S009450/1). M.M. is supported by a Wolfson Merit Award from the Royal Society. J.LS.F. is supported by the Sao Paulo Research Foundation (FAPESP grant 2019/01578-2 and 2016/12855-9), and F.T.M.C is supported by the Sao Paulo Research Foundation (FAPESP grant 2017/18611-7). |
| Keywords: | Biomass, bone marrow, spleen, hematopoiesis, malaria, reservoir. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Marti, Professor Matthias and Da Silva Filho, Dr Joao |
| Authors: | Silva-Filho, J. L., Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M., and Costa, F. T.M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Parasitology |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 1471-4922 |
| ISSN (Online): | 1471-5007 |
| Published Online: | 31 March 2020 |
| Copyright Holders: | Copyright © 2020 Crown Copyright |
| First Published: | First published in Trends in Parasitology 36(5): 447-458 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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