Re‐analysis of “Peptidomic analysis of cartilage and subchondral bone in OA patients”

Pejchinovski, M. and Mischak, H. (2020) Re‐analysis of “Peptidomic analysis of cartilage and subchondral bone in OA patients”. European Journal of Clinical Investigation, 50(8), e13240. (doi: 10.1111/eci.13240) (PMID:32306374)

Abstract

In the May 2019 issue of European Journal of Clinical Investigation, Gatenholm et al. reported on "a method for directly analyzing osteochondral samples straight out of the operating room without cell culturing, thereby enabling identification of potential peptide biomarkers to better understand the mechanisms involved in the development of osteoarthritis (OA) and pain"1. Six Samples from patients were investigated, 3 from wounded (WO) and 3 from macroscopically unwounded zones (UOA) of the femur condyle, manifesting OA based on total knee arthroplasty (TKA). Using peptidomics and Tandem Mass Tag (TMT) labeling, the authors in their study reported the identification of 6296 endogenous peptides derived from 915 proteins (889 protein groups) across samples.

• Item Type: Articles (Letter)
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mischak, Professor Harald
• Authors: Pejchinovski, M., and Mischak, H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: European Journal of Clinical Investigation
• Publisher: Wiley
• ISSN: 0014-2972
• ISSN (Online): 1365-2362
• Published Online: 18 April 2020
• Copyright Holders: Copyright © 2020 Stitching European Society for Clinical Investigation Journal Foundation
• First Published: First published in European Journal of Clinical Investigation 50(8): e13240
• Publisher Policy: Reproduced in accordance with the publisher copyright policy