Ainslie-McLaren, G. , Fee, A., McKinstray, J., Lee, A. B. and Bolster, A. A. (2020) Red cell volume measurement - using indium as a replacement for chromium. Nuclear Medicine Communications, 41(6), pp. 589-596. (doi: 10.1097/MNM.0000000000001185) (PMID:32282637)
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Abstract
The withdrawal of Cr-chromate has meant that the technique commonly used for direct measurement of red cell volume has had to be replaced. Most centres moved to a Tc erythrocyte label, however, Tc is known to dissociate over time. We have investigated an alternative technique using an In-chloride and tropolone solution and tested this both in vitro and in vivo. Initial in-vitro and in-vivo work, which included a check of the stability of the radio-labelled product at one hour, demonstrated this label to be stable over this time period. To date, 20 patients have undergone this technique and results show that this technique is a viable alternative to Cr-chromate particularly for patients with splenomegaly who require late sampling. This procedure is now in routine use in our institution.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Bolster, Dr Alison and Ainslie-McLaren, Dr Gillian |
| Authors: | Ainslie-McLaren, G., Fee, A., McKinstray, J., Lee, A. B., and Bolster, A. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Nuclear Medicine Communications |
| Publisher: | Lippincott, Williams & Wilkins |
| ISSN: | 0143-3636 |
| ISSN (Online): | 1473-5628 |
| Published Online: | 10 April 2020 |
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