Estimating the value of new antimicrobials in the context of antimicrobial resistance: development and application of a dynamic disease transmission model

Gordon, J. et al. (2020) Estimating the value of new antimicrobials in the context of antimicrobial resistance: development and application of a dynamic disease transmission model. PharmacoEconomics, 38, pp. 857-869. (doi: 10.1007/s40273-020-00906-6) (PMID:32249396)

Abstract

Objectives: Antimicrobial resistance (AMR) represents a significant threat to patient and population health. The study aim was to develop and validate a model of AMR that defines and quantifies the value of new antibiotics. Methods: A dynamic disease transmission and cost-effectiveness model of AMR consisting of three components (disease transmission, treatment pathway and optimisation) was developed to evaluate the health economic value of new antibiotics. The model is based on the relationship between AMR, antimicrobial availability and consumption. Model analysis explored the impact of different antibiotic treatment strategies on the development of AMR, patient and population estimates of health benefit, across three common treatment indications and pathogens in the UK. Results: Population-level resistance to existing antimicrobials was estimated to increase from 10.3 to 16.1% over 10 years based on current antibiotic availability and consumption. In comparison, the diversified use of a new antibiotic was associated with significant reduction in AMR (12.8% vs. 16.1%) and quality-adjusted life year (QALY) gains at a patient (7.7–10.3, dependent on antimicrobial efficacy) and population level (3657–8197, dependent on antimicrobial efficacy and the prevalence of AMR). Validation across several real-world data sources showed that the model output does not tend to systematically under- or over-estimate observed data. Conclusions: The development of new antibiotics and the appropriate use of existing antibiotics are key to addressing the threat of AMR. This study presents a validated model that quantifies the value of new antibiotics through clinical and economic outcomes of relevance, and accounts for disease transmission of infection and development of AMR. In this context, the model may be a useful tool that could contribute to the decision-making process alongside other potential models and expert advice.

• Item Type: Articles
• Additional Information: This study was funded by Pfzer.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hawkins, Professor Neil
• Authors: Gordon, J., Darlington, O., McEwan, P., Lumley, M., Taie, A., Hicks, M., Charbonneau, C., Blake, A., Hawkins, N., Goldenberg, S., Otter, J., and Wilcox, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
• Journal Name: PharmacoEconomics
• Publisher: Springer
• ISSN: 1170-7690
• ISSN (Online): 1179-2027
• Published Online: 06 April 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in PharmacoEconomics 38:857–869
• Publisher Policy: Reproduced under a Creative Commons License