Genome sequence of human cytomegalovirus Ig-KG-H2, a variant of strain KG propagated in the presence of neutralizing antibodies

Al Qaffas, A., Camiolo, S. , Nichols, J. , Davison, A. J. , Ourahmane, A., Cui, X., Schleiss, M. R., Hertel, L., Dittmer, D. P. and McVoy, M. A. (2020) Genome sequence of human cytomegalovirus Ig-KG-H2, a variant of strain KG propagated in the presence of neutralizing antibodies. Microbiology Resource Announcements, 9(17), e00063-20. (doi: 10.1128/MRA.00063-20) (PMID:32327516) (PMCID:PMC7180270)

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Abstract

Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence of several mutations in each virus.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Camiolo, Dr Salvatore and Nichols, Mrs Jenna and Davison, Professor Andrew
Authors: Al Qaffas, A., Camiolo, S., Nichols, J., Davison, A. J., Ourahmane, A., Cui, X., Schleiss, M. R., Hertel, L., Dittmer, D. P., and McVoy, M. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Microbiology Resource Announcements
Publisher:American Society for Microbiology
ISSN:2576-098X
ISSN (Online):2576-098X
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Microbiology Resource Announcements 9(17):e00063-20
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174258Exploiting a human challenge model to understand the pathogenesis of cytomegalovirusAndrew DavisonWellcome Trust (WELLCOTR)204870/Z/16/Z (17/0008)III-MRC-GU Centre for Virus Research
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH