The role of microvascular tortuosity in tumor transport phenomena and future perspective for drug delivery

Penta, R. and Ambrosi, D. (2015) The role of microvascular tortuosity in tumor transport phenomena and future perspective for drug delivery. PAMM: Proceedings in Applied Mathematics and Mechanics, 15(1), pp. 101-102. (doi: 10.1002/pamm.201510041)

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Abstract

We tackle the fluid transport problem in vascularized tumors by solving a double Darcy model obtained via multiscale homogenization. The hydraulic conductivities of the capillary and interstitial compartments are computed solving classical problems on the representative periodic cell, which encodes details of the microvasculature. Microvascular tortuosity leads to a dramatic decrease of the capillary hydraulic conductivity, and the corresponding lowering in the pressure drop impairs tumor blood flow and consequently advection of molecules. Further perspectives for anti‐cancer agents delivery are illustrated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Penta, Dr Raimondo
Authors: Penta, R., and Ambrosi, D.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:PAMM: Proceedings in Applied Mathematics and Mechanics
Publisher:Wiley
ISSN:1617-7061
ISSN (Online):1617-7061

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