Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis

Gracie, J., Leung, B. and McInnes, I. (2002) Novel pathways that regulate tumor necrosis factor-alpha production in rheumatoid arthritis. Current Opinion in Rheumatology, 14, pp. 270-275. (doi: 10.1097/00002281-200205000-00013) (PMID:11981325)

Abstract

Clinical intervention studies have clearly shown the benefit in suppressing tumor necrosis factor-alpha (TNF-alpha) rheumatoid arthritis (RA). In consequence, considerable interest has arisen in those pathways that in turn regulate TNF-alpha production, because they may offer further possible therapeutic targets. Several candidate pathways are currently being investigated. They include T cell/macrophage interactions mediated primarily through cell-cell membrane contact; novel cytokine activities; microbial-derived products, in particular bacterial deoxyribonucleic acid sequences; autoreactive T cells, and immunoglobulins. At the subcellular level, there is further interest in targeting signaling and mRNA processing and cytokine cleavage pathways required for optimal TNF-alpha production. The key recent observations in these areas, particularly in the extracellular compartment, are reviewed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McInnes, Professor Iain and Leung, Dr Bernard
• Authors: Gracie, J., Leung, B., and McInnes, I.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Current Opinion in Rheumatology
• ISSN: 1040-8711