Mitochondrial DNA in inflammation and immunity

Riley, J. S. and Tait, S. W.G. (2020) Mitochondrial DNA in inflammation and immunity. EMBO Reports, 21(4), e49799. (doi: 10.15252/embr.201949799) (PMID:32202065) (PMCID:PMC7132203)

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Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation. Despite this seemingly symbiotic relationship, mitochondria harbour within them a potent agonist of innate immunity: their own genome. Release of mitochondrial DNA into the cytoplasm and out into the extracellular milieu activates a plethora of different pattern recognition receptors and innate immune responses, including cGAS‐STING, TLR9 and inflammasome formation leading to, among others, robust type I interferon responses. In this Review, we discuss how mtDNA can be released from the mitochondria, the various inflammatory pathways triggered by mtDNA release and its myriad biological consequences for health and disease.

Item Type:Articles
Additional Information:Research in our laboratory is supported by funding from Cancer Research UK and Prostate Cancer UK.
Glasgow Author(s) Enlighten ID:Riley, Dr Joel and Tait, Professor Stephen
Authors: Riley, J. S., and Tait, S. W.G.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:EMBO Reports
Publisher:EMBO Press
ISSN (Online):1469-3178
Published Online:23 March 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in EMBO Reports 21(4): e39799
Publisher Policy:Reproduced under a Creative Commons License

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